Which area you farm is decided by the area's monster level, not by the item —
the rule is the same for everything, so it lives on the
mechanics page.
NAMED TARGETS
Named monsters that can be farmed deliberately. The list spans all three difficulties;
each monster appears once, at its most rewarding one.
The figure is an estimated average kill count.
Duriel
nightmare · Lv 55~1 every 2,060 kills
The Cow King
nightmare · Lv 61~1 every 2,610 kills